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Strumentazione Analitica

LCMS-8050

UFscanning

High-Sensitivity & High-Speed Scanning at 30,000 u/sec

Simultaneous Quantitative and Qualitative Analysis

Simultaneous High-Speed Screening of 12 Toxicological Drugs

The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step.

UFscanning

MRM Triggered Product Ion Scanning of a Mixture of 12 Benzodiazepines (1 ng/mL each)

 

UFswitching

High-Sensitivity & High-Speed Positive/Negative Ionization Switching in 5 msec

Just One Minute per Analysis

A Case Study Using High-Speed Positive/Negative Ionization Switching

When performing simultaneous positive/negative ion measurements of multiple components, the proper acquisition of sharp UHPLC peaks depends on rapid polarity switching. The LCMS-8050 minimizes losses due to polarity switching and ensures the collection of sufficient data points for even the narrow peaks obtained with UHPLC, recording accurate peak shapes and allowing excellent reproducibility.

UFswitching

UF-MRM

High-Sensitivity & High-Speed MRM at 555 ch/sec

Detect Target Compounds at Trace-Level Concentrations

Simultaneous Analysis of 29 Pesticides for Water Quality Analysis

The LCMS-8050 is capable of simultaneously acquiring 555 MRM transitions per second while maintaining accuracy and precision. Sufficient data points can be collected for quantitation ions, reference ions, and internal standard ions even in chromatographic regions with unresolved peaks. The high sensitivity of the LCMS-8050 allows for trace-level analysis, such as pesticides in drinking water, without the need for sample pre-concentration. This high sensitivity is maintained even when monitoring numerous MRM channels.

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LCMS-8060

The LCMS-8060 is a ground breaking innovation in mass spectrometry helping to transform LC/MS/MS data quality by developing a new vision of sensitivity and speed.
Shimadzu is the first mass spectrometry company in the world to deliver a triple quadrupole mass spectrometer with the highest sensitivity and ultra-fast technologies to create an innovation that really matters.

 

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i-Series

 

The i-series, designed for covering conventional to ultra-fast LC applications, consists of the compact HPLC Prominence-i and UHPLC system Nexera-i. High speed analysis, simplified method transfer, minimized environmental impact and easy maintenance are just a few of the many new features of this product range

Instruments of the i-series will meet or exceed any expectation for robustness and reliability. In addition, new functionalities, such as remote-monitoring with smart devices and the quick-batch-function for quick and easy creation of sequential analyses are added to make the i-series the integrated HPLC system of choice.

The i-series can be widely utilized in CMC related analyses and confirmation of synthetic compounds including method development/optimization and product QA/QC, dissolution testing of generic drugs and remote-monitoring of manufacturing processes of new drug candidates.

 

 

 

Realization of Advanced Laboratory

  • ICM (Interactive Communication Mode) to free operators from the laboratory
  • Remote monitoring regardless of operating environment
  • Maximum reliability and stability

Achieving Easier Operation

  • Unified graphical user interface between system and workstation
  • Create analytical sequences on visualized vial positions: Quick batch function

Smart Features Increase Work Efficiency

  • Automation of a number of routine analysis procedures
  • Migrate existing methods from either Shimadzu or non-Shimadzu systems
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Crude2Pure

When purifying target compounds from extracts of natural products and synthetic substances via preparative LC, powderization of the target compounds of the fraction is an important process. Ordinarily, it takes time to purify and powderize the target compounds obtained by the preparative LC. It is also difficult to recover high-purity powder.
The Crude2Pure system, which is based on ground-breaking purification methods, provides a new approach that reduces the work of the purification/powderization process after preparation.

Crude2Pure Automated Purification LC SystemTM

The Crude2Pure system consists of a trapping system equipped with a dedicated Shim-pack C2P-H column for trapping and concentrating the target compound, and a recovery system that automatically powderizes and recovers the trapping target compound.
Single and multi-system configurations are available to meet specific operational requirements.

Retention and Concentration of Compounds —Crude2Pure Trapping System—

Ordinarily, when removing solvents, it is necessary to evaluate detailed conditions for each compound. With the Crude2Pure, however, simply place the preparative LC fraction in the autosampler, and enter the compound information into the interactive software to automatically trap the compound. In addition, the newly developed Shim-pack C2P-H trapping column can be used with a wide range of organic solvents and pH conditions, and provides high loading and high recovery rates. Further, trapping conditions are determined from the information on retention times obtained during fractionation, so there is no need to evaluate conditions individually. This eliminates the need to perform difficult preliminary evaluations to determine trapping conditions.

Powderizing Compounds —Crude2Pure Recovery System—

This stage recovers the target compound trapped in the trapping column and then simultaneously powderizes it. In addition, it can perform desalination and salt substitution as is, prior to recovery.
The sequence from pretreatment to powderization takes approximately three to four hours, which saves a great deal of time in comparison to centrifugal concentration or freeze drying. The vial in which the powderized target compound is recovered can be used as a storage container as is, eliminating the need to transfer the samples. Furthermore, adding the changer option increases the throughput of drying and powderization via 6-line parallel processing (multi system).

 

Flexible System Configurations

 

Basic Crude2Pure System (Single Recovery System)

This is the simplest Crude2Pure system. The trapping system can process up to four samples and the recovery system two samples.
(Expansion to a multi system is possible.)

 

Multi Recovery System Supporting Multi-sample Processing

 

This is recommended for multi-sample processing. The sample concentrated by the single trapping system is processed continuously by the multi recovery system. The recovery system accommodates up to 48 samples. The dedicated software, which is compatible with open access, allows setting of the trapping columns to the recovery system during operation.

 

 

Expansion from the Basic System (Multi Trapping / Recovery System)

 

If more throughput is required, the trapping system and the recovery system can be expanded to a multi system by adding rack changers, etc.

 

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Nexera Method Scouting

Ultra High Performance Liquid Chromatograph Method Scouting System

Maximizing Efficiency for Method Development

The Nexera Method Scouting System design of the Nexera Method Scouting is based on the Nexera next-generation ultra high performance liquid chromatograph. It uses system uses the special Method Scouting Solution control software and a robust, high-pressure resistant column switching system to switch mobile phases and columns automatically, achieving a quick and accurate method scouting workflow. As a result, this system provides strong support for efficient HPLC method development.
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Nexera XR

The Most Accessible UHPLC Available

Developed with expandability and compatibility in mind, the Nexera XR ultra high performance liquid chromatograph enables more customers to make use of high-speed, high-resolution systems. Configure the optimal system to meet the specific analysis objective by selecting from among a wide range of highly accurate and reliable modules. The next milestone in the evolution of liquid chromatography, the Nexera XR promises to become an indispensable tool in laboratories in a variety of fields, including pharmaceuticals, biochemistry, chemistry, environmental, and foods.

Expanding the Possibilities of UHPLC

Superb Functionality

Accuracy and reproducibility of solvent delivery and injection volume are particularly important performance aspects. Shimadzu addressed these features by incorporating superb technology as a fundamental element. Furthermore, improved hardware components support high-speed analyses, which have accelerated via advances in column technology.
As the most accessible UHPLC available, with a pressure resistance of 66 MPa, the Nexera XR truly provides the optimal solution for a diverse range of applications.

Extensive Lineup

A solvent delivery unit compatible with small-capacity, low-pressure gradient units is the latest addition to the Nexera XR lineup. With its modular design, the Nexera XR allows configuration of systems geared to meet specific application requirements. Each module delivers excellent, reliable performance across an extensive analytical range, from HPLC to UHPLC.

Balancing Performance with User-Friendliness

The most accessible UHPLC available, the Nexera XR provides excellent performance while ensuring ease-of-use. In addition, although the Nexera XR is in the UHPLC category, the replacement frequency for consumables has been kept to a minimum, making the ease of maintenance comparable to that of an HPLC system.

Method Compatibility

Constructed with a focus on compatibility with general UHPLC systems, the Nexera XR is optimized for method transfer from competing systems. In addition, the system capacity can be changed to suit the objective, enabling smooth HPLC method transfer.

Detectors Offering World-Leading* Sensitivity

The SPD-M30A photodiode array detector and the RF-20Axs fluorescence detector offer world-leading sensitivity. Equipped with a temperature control function to suppress the effects of room temperature fluctuations, these detectors achieve excellent baseline stability and reproducibility.

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Nexera MP

Ultra-high-speed multi-sample processing using SIL-30ACMP Multiplate Autosampler

 To speed up R&D in such areas as pharmacokinetics (drug manufacturing), it has become increasingly necessary to analyze large numbers of samples at high speed and high precision. In response to these demands, the new Nexera MP Ultra High Performance Liquid Chromatograph utilizing the SIL-30ACMP Multiplate Autosampler was developed. The SIL-30ACMP achieves an ultrafast injection performance exceeding that of current models while maintaining ultralow carryover performance. In addition, up to 6 microtiter plates can be loaded, enabling a maximum of 2304 samples to be analyzed continuously. By incorporating these various functions, the Nexera MP is ideally suited as a front-end LC for LC/MS and LC/MS/MS systems.

More Speed

•High-speed injection significantly improves throughput in multi-sample processing

More Reliable

•Ultralow (near-zero) carryover•Outstanding injection mechanism assures precision when injecting trace amounts

More Capacity
•Open access design enables the loading of samples, even during analysis

Reliable performance supports high-precision LC/MS/MS analysis

•Example of drug interaction testing•CTO-30AS Column Oven – Minimizes the column-mass spectrometer distance

Open access improves analysis efficiency

– Helps build an analysis environment in which two or more researchers can comfortably share one system

 

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AXIMA Confidence

Taking MALDI-TOF MS Beyond the Standard

AXIMA Confidence

  • Powerful MALDI-TOF performance for reliable mass information and MS/MS derived structural detail.
  • Linear mode allows the interrogation of high molecular weight samples, whilst reflectron mode, incorporating the patented curved-field reflectron (CFR), provides the high resolution and mass accuracy necessary for successful proteomics and life science experiments.
  • High sensitivity system using a variable repetition rate 50 Hz N2 laser and a variety of target formats to meet all sample throughput requirements.
  • An affordable robust option for all laboratories requiring routine manual or automated analysis of a wide variety of sample classes.
  • Excellent sensitivity is achieved using near-axis laser irradiation and advanced ion optics for enhanced ion transmission.
  • MS/MS may be easily performed using a seamless approach – ions of interest can be isolated using a precursor ion selection device, incorporated as standard, and data-rich fragment ion spectra quickly and simply acquired.The newly improved curved field reflectron design augments the low mass fragment region providing useful additional information.
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AXIMA Resonance

Ultimate MALDI MS and MSn Performance

Combining the simplicity of MALDI, the power of MSn, and the accuracy and resolution of TOF, the AXIMA Resonance provides researchers a unique solution to the next generation of structural and sequencing challenges. Designed without compromise, the AXIMA Resonance features high mass resolution and mass accuracy across MS and MSn analyses, excellent precursor ion selection, variable energy CID control on the fly, and outstanding sensitivity to ensure confident, high-quality results across a range of applications.

Advanced MSn Performance

The unique combination of MALDI and QIT allows generation of ions using a number of different matrices; switching between positive and negative ionization modes in seconds; simple high resolution precursor ion selection for MSn experiments, and controllable MSn fragmentation.

Incorporating a TOF analyzer promotes high resolution and high mass accuracy for all ions generated regardless of their origin.

Excellent Precursor Ion Selection

AXIMA Resonance

Allows ions from complex mixtures or closely associated neighboring isotopic envelopes to be easily isolated and subsequently fragmented; trapping resolution greater than 1000 FWHM permits the analysis of samples with similar nominal mass
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AXIMA Assurance

High Performance Mass Detection

AXIMA Assurance

  • Linear MALDI-TOF mass spectrometry for reliable mass information.
  • An affordable, robust option for all laboratories requiring routine manual or automated analysis of a wide variety of sample classes.
  • High sensitivity system using a variable repetition rate 50 Hz N2 laser and a variety of target formats to meet all sample throughput requirements.
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